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작성일 : 13-11-16 11:33
2013-11-16 저널 발표 이승호
 글쓴이 : 관리자
조회 : 844  
Fear Extinction Causes Target-Specific Remodeling of Perisomatic Inhibitory Synapses
Summary
A more complete understanding of how fear extinction alters neuronal activity and connectivity within fear circuits may aid in the development of strategies to treat human fear disorders. Using a c-fos-based transgenic mouse, we found that contextual fear extinction silenced basal amygdala (BA) excitatory neurons that had been previously activated during fear conditioning. We hypothesized that the silencing of BA fear neurons was caused by an action of extinction on BA inhibitory synapses. In support of this hypothesis, we found extinction-induced target-specific remodeling of BA perisomatic inhibitory synapses originating from parvalbumin and cholecystokinin-positive interneurons. Interestingly, the predicted changes in the balance of perisomatic inhibition matched the silent and active states of the target BA fear neurons. These observations suggest that target-specific changes in perisomatic inhibitory synapses represent a mechanism through which experience can sculpt the activation patterns within a neural circuit.
 

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<a href="https://ccmdy.com/" target="_blank" title="카지노">카지노</a>
<a href="https://ccmdy.com/" target="_blank" title="바카라">바카라</a>
dkswjsgo 18-07-28 16:30
 
<a href="https://ccmdy.com/" target="_blank" title="다빈치카지노">다빈치카지노</a>
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dkswjsgo 18-07-28 16:31
 
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dkswjsgo 18-07-28 16:35
 
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dkswjsgo 18-07-28 16:36
 
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dkswjsgo 18-10-09 22:58
 
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Total 212
번호 제   목 글쓴이 날짜 조회
12 2014-02-08 저널 발표 손유진 (1) 관리자 02-06 1046
11 2014-01-25 저널 발표 정태양 (1) 관리자 01-23 990
10 2014-01-18 저널 발표 이상현 (1) 관리자 01-16 858
9 2014-01-11 저널 발표 이주한 관리자 01-06 877
8 2014-01-04 저널 발표 김수정 (1) 관리자 12-31 945
7 2013-12-28 저널 발표 김영규 관리자 12-24 925
6 2013-12-21 저널 발표 조희정 (1) 관리자 12-18 1045
5 2013-12-14 저널 발표 손유진 (1) 관리자 12-12 876
4 2013-12-07 저널 발표 정정훈 (1) 관리자 12-03 1157
3 2013-11-30 저널 발표 김현진 관리자 11-25 890
2 2013-11-23 저널 발표 안경만 안경만 11-18 944
1 2013-11-16 저널 발표 이승호 (26) 관리자 11-16 845
   11