Board > Board > 2018-04-14 저널 발표 조희정
HOME 로그인 회원가입 사이트맵
 
작성일 : 18-04-10 19:19
2018-04-14 저널 발표 조희정
 글쓴이 : 관리자
조회 : 122  
 2018 Mar 22;173(1):140-152.e15. 

A Neural Circuit for the Suppression of Pain by a Competing Need State.


Abstract

Hunger and pain are two competing signals that individuals must resolve to ensure survival. However, the neural processes that prioritize conflicting survival needs are poorly understood. We discovered that hunger attenuates behavioral responses and affective properties of inflammatory pain without altering acute nociceptive responses. This effect is centrally controlled, as activity in hunger-sensitive agouti-related protein (AgRP)-expressing neurons abrogates inflammatory pain. Systematic analysis of AgRP projection subpopulations revealed that the neural processing of hunger and inflammatory pain converge in the hindbrain parabrachial nucleus (PBN). Strikingly, activity in AgRP → PBN neurons blocked the behavioral response to inflammatory pain as effectively as hunger or analgesics. The anti-nociceptive effect of hunger is mediated by neuropeptide Y (NPY) signaling in the PBN. By investigating the intersection between hunger and pain, we have identified a neural circuit that mediates competing survival needs and uncovered NPY Y1 receptor signaling in the PBN as a target for pain suppression.


http://www.cell.com/cell/fulltext/S0092-8674(18)30234-4



 
 

Total 211
번호 제   목 글쓴이 날짜 조회
211 2018-06-16 저널 발표 이주한 관리자 06-16 14
210 2018-06-09 저널 발표 이승호 관리자 06-08 25
209 2018-05-26 저널 발표 고범진 관리자 05-26 51
208 2018-05-19 저널 발표 이주한 관리자 05-17 76
207 2018-05-12 저널 발표 이현용 관리자 05-11 91
206 2018-04-21 저널 발표 고범진 관리자 04-17 112
205 2018-04-14 저널 발표 조희정 관리자 04-10 123
204 2018-04-07 저널 발표 이승호 관리자 04-04 129
203 2018-03-24 저널 발표 이주한 관리자 03-22 162
202 2018-03-17 저널 발표 이현용 관리자 03-16 171
201 2018-03-10 저널 발표 정민재 관리자 03-09 185
200 2018-03-03 저널 발표 고범진 관리자 03-02 385
199 2018-02-24 저널 발표 조희정 관리자 02-23 168
198 2018-02-10 저널 발표 이승호 관리자 02-08 209
197 2018-02-03 저널 발표 이주한 관리자 01-31 284
196 2018-01-27 저널 발표 김현진 관리자 01-23 242
195 2018-01-20 저널 발표 이현용 관리자 01-19 243
194 2018-01-13 저널 발표 조희정 관리자 01-11 360
193 2018-01-06 저널 발표 고범진 관리자 01-02 342
192 2017-12-30 저널 발표 윤경화 관리자 12-27 308
 1  2  3  4  5  6  7  8  9  10