Board > Board > 2018-04-14 저널 발표 조희정
HOME 로그인 회원가입 사이트맵
 
작성일 : 18-04-10 19:19
2018-04-14 저널 발표 조희정
 글쓴이 : 관리자
조회 : 174  
 2018 Mar 22;173(1):140-152.e15. 

A Neural Circuit for the Suppression of Pain by a Competing Need State.


Abstract

Hunger and pain are two competing signals that individuals must resolve to ensure survival. However, the neural processes that prioritize conflicting survival needs are poorly understood. We discovered that hunger attenuates behavioral responses and affective properties of inflammatory pain without altering acute nociceptive responses. This effect is centrally controlled, as activity in hunger-sensitive agouti-related protein (AgRP)-expressing neurons abrogates inflammatory pain. Systematic analysis of AgRP projection subpopulations revealed that the neural processing of hunger and inflammatory pain converge in the hindbrain parabrachial nucleus (PBN). Strikingly, activity in AgRP → PBN neurons blocked the behavioral response to inflammatory pain as effectively as hunger or analgesics. The anti-nociceptive effect of hunger is mediated by neuropeptide Y (NPY) signaling in the PBN. By investigating the intersection between hunger and pain, we have identified a neural circuit that mediates competing survival needs and uncovered NPY Y1 receptor signaling in the PBN as a target for pain suppression.


http://www.cell.com/cell/fulltext/S0092-8674(18)30234-4



 
 

Total 212
번호 제   목 글쓴이 날짜 조회
212 2018-06-23 저널 발표 조희정 관리자 06-23 96
211 2018-06-16 저널 발표 이주한 관리자 06-16 112
210 2018-06-09 저널 발표 이승호 관리자 06-08 112
209 2018-05-26 저널 발표 고범진 관리자 05-26 115
208 2018-05-19 저널 발표 이주한 관리자 05-17 144
207 2018-05-12 저널 발표 이현용 관리자 05-11 143
206 2018-04-21 저널 발표 고범진 관리자 04-17 156
205 2018-04-14 저널 발표 조희정 관리자 04-10 175
204 2018-04-07 저널 발표 이승호 관리자 04-04 166
203 2018-03-24 저널 발표 이주한 관리자 03-22 199
202 2018-03-17 저널 발표 이현용 관리자 03-16 215
201 2018-03-10 저널 발표 정민재 관리자 03-09 223
200 2018-03-03 저널 발표 고범진 관리자 03-02 442
199 2018-02-24 저널 발표 조희정 관리자 02-23 206
198 2018-02-10 저널 발표 이승호 관리자 02-08 241
197 2018-02-03 저널 발표 이주한 관리자 01-31 331
196 2018-01-27 저널 발표 김현진 관리자 01-23 279
195 2018-01-20 저널 발표 이현용 관리자 01-19 288
194 2018-01-13 저널 발표 조희정 관리자 01-11 413
193 2018-01-06 저널 발표 고범진 관리자 01-02 402
 1  2  3  4  5  6  7  8  9  10