Board > Board > 2017-09-09 저널 발표 조희정
HOME 로그인 회원가입 사이트맵
 
작성일 : 17-09-08 21:51
2017-09-09 저널 발표 조희정
 글쓴이 : 관리자
조회 : 626  
 2017 Aug 21. 

Central amygdala circuits modulate food consumption through a positive-valence mechanism.


Abstract

The complex behaviors underlying reward seeking and consumption are integral to organism survival. The hypothalamus and mesolimbic dopamine system are key mediators of these behaviors, yet regulation of appetitive and consummatory behaviors outside of these regions is poorly understood. The central nucleus of the amygdala (CeA) has been implicated in feeding and reward, but the neurons and circuit mechanisms that positively regulate these behaviors remain unclear. Here, we defined the neuronal mechanisms by which CeA neurons promote food consumption. Using in vivo activity manipulations and Ca2+ imaging in mice, we found that GABAergic serotonin receptor 2a (Htr2a)-expressing CeA neurons modulate food consumption, promote positive reinforcement and are active in vivo during eating. We demonstrated electrophysiologically, anatomically and behaviorally that intra-CeA and long-range circuit mechanisms underlie these behaviors. Finally, we showed that CeAHtr2a neurons receive inputs from feeding-relevant brain regions. Our results illustrate how defined CeA neural circuits positively regulate food consumption.


http://www.nature.com/neuro/journal/vaop/ncurrent/full/nn.4623.html



 
 

Total 212
번호 제   목 글쓴이 날짜 조회
212 2018-06-23 저널 발표 조희정 관리자 06-23 53
211 2018-06-16 저널 발표 이주한 관리자 06-16 75
210 2018-06-09 저널 발표 이승호 관리자 06-08 80
209 2018-05-26 저널 발표 고범진 관리자 05-26 91
208 2018-05-19 저널 발표 이주한 관리자 05-17 115
207 2018-05-12 저널 발표 이현용 관리자 05-11 127
206 2018-04-21 저널 발표 고범진 관리자 04-17 140
205 2018-04-14 저널 발표 조희정 관리자 04-10 159
204 2018-04-07 저널 발표 이승호 관리자 04-04 152
203 2018-03-24 저널 발표 이주한 관리자 03-22 186
202 2018-03-17 저널 발표 이현용 관리자 03-16 198
201 2018-03-10 저널 발표 정민재 관리자 03-09 209
200 2018-03-03 저널 발표 고범진 관리자 03-02 418
199 2018-02-24 저널 발표 조희정 관리자 02-23 191
198 2018-02-10 저널 발표 이승호 관리자 02-08 227
197 2018-02-03 저널 발표 이주한 관리자 01-31 312
196 2018-01-27 저널 발표 김현진 관리자 01-23 263
195 2018-01-20 저널 발표 이현용 관리자 01-19 268
194 2018-01-13 저널 발표 조희정 관리자 01-11 381
193 2018-01-06 저널 발표 고범진 관리자 01-02 366
 1  2  3  4  5  6  7  8  9  10