Board > Board > 2017-07-08 저널 발표 정민재
HOME 로그인 회원가입 사이트맵
 
작성일 : 17-07-07 11:43
2017-07-08 저널 발표 정민재
 글쓴이 : 관리자
조회 : 554  
 2017 Jun;20(6):784-792.

Abnormal wiring of CCK+ basket cells disrupts spatial information coding.


Abstract

The function of cortical GABAergic interneurons is largely determined by their integration into specific neural circuits, but the mechanisms controlling the wiring of these cells remain largely unknown. This is particularly true for a major population of basket cells that express the neuropeptide cholecystokinin (CCK). Here we found that the tyrosine kinase receptor ErbB4 was required for the normal integration into cortical circuits of basket cells expressing CCK and vesicular glutamate transporter 3 (VGlut3). The number of inhibitory synapses made by CCK+VGlut3+ basket cells and the inhibitory drive they exerted on pyramidal cells were reduced in conditional mice lacking ErbB4. Developmental disruption of the connectivity of these cells diminished the power of theta oscillations during exploratory behavior, disrupted spatial coding by place cells, and caused selective alterations in spatial learning and memory in adult mice. These results suggest that normal integration of CCK+ basket cells in cortical networks is key to support spatial coding in the hippocampus.


https://www.nature.com/neuro/journal/v20/n6/full/nn.4544.html






 
 

Total 212
번호 제   목 글쓴이 날짜 조회
212 2018-06-23 저널 발표 조희정 관리자 06-23 53
211 2018-06-16 저널 발표 이주한 관리자 06-16 75
210 2018-06-09 저널 발표 이승호 관리자 06-08 80
209 2018-05-26 저널 발표 고범진 관리자 05-26 91
208 2018-05-19 저널 발표 이주한 관리자 05-17 115
207 2018-05-12 저널 발표 이현용 관리자 05-11 127
206 2018-04-21 저널 발표 고범진 관리자 04-17 140
205 2018-04-14 저널 발표 조희정 관리자 04-10 159
204 2018-04-07 저널 발표 이승호 관리자 04-04 152
203 2018-03-24 저널 발표 이주한 관리자 03-22 186
202 2018-03-17 저널 발표 이현용 관리자 03-16 198
201 2018-03-10 저널 발표 정민재 관리자 03-09 209
200 2018-03-03 저널 발표 고범진 관리자 03-02 418
199 2018-02-24 저널 발표 조희정 관리자 02-23 191
198 2018-02-10 저널 발표 이승호 관리자 02-08 227
197 2018-02-03 저널 발표 이주한 관리자 01-31 312
196 2018-01-27 저널 발표 김현진 관리자 01-23 263
195 2018-01-20 저널 발표 이현용 관리자 01-19 268
194 2018-01-13 저널 발표 조희정 관리자 01-11 381
193 2018-01-06 저널 발표 고범진 관리자 01-02 366
 1  2  3  4  5  6  7  8  9  10