Board > Board > 2014-01-18 저널 발표 이상현
HOME 로그인 회원가입 사이트맵
 
작성일 : 14-01-16 16:39
2014-01-18 저널 발표 이상현
 글쓴이 : 관리자
조회 : 858  

Nature Neuroscience | Article

Age-dependent regulation of synaptic connections by dopamine D2 receptors

Jie-Min Jia,1 Jun Zhao,1 Zhonghua Hu,1 Daniel Lindberg1 & Zheng Li1

 

Dopamine D2 receptors (D2R) are G protein–coupled receptors that modulate synaptic transmission and are important for various brain functions, including learning and working memory. Abnormal D2R signaling has been implicated in psychiatric disorders such as schizophrenia. Here we report a new function of D2R in dendritic spine morphogenesis. Activation of D2R reduced spine number via GluN2B- and cAMP-dependent mechanisms in mice. Notably, this regulation occurred only during adolescence. During this period, D2R overactivation caused by mutations in the schizophrenia risk gene Dtnbp1 led to spine deficiency, dysconnectivity in the entorhinal-hippocampal circuit and impairment of spatial working memory. Notably, these defects could be ameliorated by D2R blockers administered during adolescence. Our findings suggest an age-dependent function of D2R in spine development, provide evidence that D2R dysfunction during adolescence impairs neuronal circuits and working memory, and indicate that adolescent interventions to prevent aberrant D2R activity protect against cognitive impairment.

 

http://www.nature.com/neuro/journal/v16/n11/full/nn.3542.html


은영마마 18-06-01 17:02
 
<a href="https://aticpay.com/theking/">더킹카지노</a>
<a href="https://aticpay.com/world/">월드카지노</a>
<a href="https://aticpay.com/woori/">우리카지노</a>
<a href="https://aticpay.com/asian/">아시안카지노</a>

<a href="https://aticpay.com/casino/">카지노사이트</a>
<a href="https://aticpay.com/davinchi/">다빈치카지노</a>
<a href="https://aticpay.com/ebiang/">에비앙카지노</a>
<a href="https://aticpay.com/f1casino/">F1카지노</a>
<a href="https://aticpay.com/gatsby/">개츠비카지노</a>

<a href="https://aticpay.com/f1ca/">에프원카지노</a>
<a href="https://aticpay.com/mca/">엠카지노</a>
<a href="https://aticpay.com/korea/">코리아카지노</a>
<a href="https://aticpay.com/live/">라이브카지노</a>
<a href="https://aticpay.com/macau/">마카오카지노</a>

<a href="https://aticpay.com/mcasino/">M카지노</a>
<a href="https://aticpay.com/mobile/">모바일카지노</a>
<a href="https://aticpay.com/pilin/">필리핀카지노</a>
<a href="https://aticpay.com/samsam/">삼삼카지노</a>
<a href="https://aticpay.com/super/">슈퍼카지노</a>

<a href="https://aticpay.com/trump/">트럼프카지노</a>
<a href="https://aticpay.com/vegas/">베가스카지노</a>
<a href="https://aticpay.com/33casino/">33카지노</a>
 
 

Total 212
번호 제   목 글쓴이 날짜 조회
12 2014-02-08 저널 발표 손유진 (1) 관리자 02-06 1046
11 2014-01-25 저널 발표 정태양 (1) 관리자 01-23 990
10 2014-01-18 저널 발표 이상현 (1) 관리자 01-16 859
9 2014-01-11 저널 발표 이주한 관리자 01-06 878
8 2014-01-04 저널 발표 김수정 (1) 관리자 12-31 946
7 2013-12-28 저널 발표 김영규 관리자 12-24 926
6 2013-12-21 저널 발표 조희정 (1) 관리자 12-18 1046
5 2013-12-14 저널 발표 손유진 (1) 관리자 12-12 877
4 2013-12-07 저널 발표 정정훈 (1) 관리자 12-03 1158
3 2013-11-30 저널 발표 김현진 관리자 11-25 891
2 2013-11-23 저널 발표 안경만 안경만 11-18 945
1 2013-11-16 저널 발표 이승호 (26) 관리자 11-16 845
   11