Board > Board > 2013-12-14 저널 발표 손유진
HOME 로그인 회원가입 사이트맵
 
작성일 : 13-12-12 11:27
2013-12-14 저널 발표 손유진
 글쓴이 : 관리자
조회 : 876  

Neuron


A Unique Population of Ventral Tegmental Area Neurons Inhibits the Lateral Habenula to Promote Reward

 

 

Alice M. Stamatakis,Joshua H. Jennings,Randall L. Ung,Grace A. Blair,Richard J. Weinberg,Rachael L. Neve,Frederick Boyce,Joanna Mattis,Charu Ramakrishnan,Karl Deisseroth,Garret D. Stubersend emailSee Affiliations

 

Lateral habenula (LHb) neurons convey aversive and negative reward conditions through potent indirect inhibition of ventral tegmental area (VTA) dopaminergic neurons. Although VTA dopaminergic neurons reciprocally project to the LHb, the electrophysiological properties and the behavioral consequences associated with selective manipulations of this circuit are unknown. Here, we identify an inhibitory input to the LHb arising from a unique population of VTA neurons expressing dopaminergic markers. Optogenetic activation of this circuit resulted in no detectable dopamine release in LHb brain slices. Instead, stimulation produced GABA-mediated inhibitory synaptic transmission, which suppressed the firing of postsynaptic LHb neurons in brain slices and increased the spontaneous firing rate of VTA dopaminergic neurons in vivo. Furthermore, in vivo activation of this pathway produced reward-related phenotypes that were dependent on intra-LHb GABAA receptor signaling. These results suggest that noncanonical inhibitory signaling by these hybrid dopaminergic-GABAergic neurons act to suppress LHb output under rewarding conditions.

https://www.cell.com/neuron/abstract/S0896-6273(13)00757-5


남현우 18-05-03 01:42
 
<a href="https://king345.com/">오바마카지노</a>
<a href="https://cablear.com/theking/">더킹카지노</a>
<a href="https://cablear.com/woori/">우리카지노</a>
<a href="https://cablear.com/33casino/">33카지노</a>
<a href="https://awwag.com/obama/">오바마카지노</a>
 
 

Total 212
번호 제   목 글쓴이 날짜 조회
12 2014-02-08 저널 발표 손유진 (1) 관리자 02-06 1046
11 2014-01-25 저널 발표 정태양 (1) 관리자 01-23 990
10 2014-01-18 저널 발표 이상현 (1) 관리자 01-16 858
9 2014-01-11 저널 발표 이주한 관리자 01-06 877
8 2014-01-04 저널 발표 김수정 (1) 관리자 12-31 945
7 2013-12-28 저널 발표 김영규 관리자 12-24 925
6 2013-12-21 저널 발표 조희정 (1) 관리자 12-18 1045
5 2013-12-14 저널 발표 손유진 (1) 관리자 12-12 877
4 2013-12-07 저널 발표 정정훈 (1) 관리자 12-03 1158
3 2013-11-30 저널 발표 김현진 관리자 11-25 891
2 2013-11-23 저널 발표 안경만 안경만 11-18 944
1 2013-11-16 저널 발표 이승호 (26) 관리자 11-16 845
   11